I know a whole load of people who are complaining about connecting to there PC with the new ActiveSync 4.1, I was one of them until I got some friendly advice from Neil Chapman about firewall settings. These can be found here.
But unfortunately that wasn't the full solution. Some of you are having problems when your connected to the PC via USB, but still not initiating a sync...
Well I found a workaround;
- Open your network connections Start > Connect To > Show All Connections

- Select the properties for the device named Windows Mobile-based device

- Ensure all the items are checked in the list box below the following This connection uses the following items
Don't ask me why these are not set as default sometimes... But hey, I'm sure it will in the next update.